The principle of the Freezer Dryer is a technique of drying with the principle of sublimation. It is a method in which the dried aqueous material is rapidly frozen at a low temperature into a solid state, and then, in a suitable vacuum environment, the frozen water molecules are sublimated directly The process by which water vapor escapes to remove moisture and retains the substance. The product obtained by freeze drying is called lyophilizer. This process is called lyophilization.
In order to ensure the biological activity and quality of the sample, it is necessary to pre-freeze the sample, freeze it in the refrigerator or freeze-drying machine, and then put it into the freeze-drying shelf. At this point the moisture in the sample in the frozen dryer under low temperature and high vacuum directly under the sublimation of steam by the low temperature cold trap and vacuum pump to catch. After tens of hours after the main dry, the vast majority of the sample of water was sublimated, and the sample was completely retained, sublimed out of the gas in the cold trap condensate for the ice, due to pressure relations, there have been gas sublimation and then Cold trap condensed into ice, ice in the sublimation to absorb heat, causing the sample itself to slow down the temperature and sublimation speed, in order to increase the sublimation speed, shorten the drying time, the product must be properly heated. In order to ensure the higher purity of the sample, this time the sample can be freeze-dried temperature can also be called after the drying process, the sample temperature can reach room temperature, all freeze-dried process is completed.
Freezer Dryer working principle advantage
1 material in the dry before always in the low temperature (frozen state), while ice crystals evenly distributed in the material, the sublimation process will not occur due to dehydration and condensation phenomenon, to avoid the water vapor bubble, oxidation and other side effects.
2 dry material was dry sponge porous volume is basically the same, no shrinkage, easily soluble in water and restore to the pre-freeze morphology.
3 The principle of common drying is by heating, but these drying methods are carried out at temperatures above 0 ° C or higher, and the dried product varies greatly in physical and chemical form. In the freeze-drying process, the growth of microorganisms and the role of enzymes can not be carried out, to the greatest extent to prevent the original dry biological substances, chemical properties of the denaturation, stability, easy to long-term preservation.
4 products in the freeze-drying chamber of the sterile state to complete the dry, desorption of water and pressure plug and other operations.
5 can remove 95% to 99% of the water in the substance.
6 For those heat-sensitive substances, such as vaccines, bacteria, toxic, blood products such as dry preservation is particularly applicable.
7 freeze-drying machine with the most structural parts of the optimal structure is conducive to transport, installation, production operations; is conducive to cleaning and maintenance, in line with GMP requirements.
★ Freezer Dryer automatic control system
Programmable Freezer Dryer, all freeze-dried process, from freeze to defrost, are controlled by the program.
★ partition heating system
The temperature uniformity is more accurate by heating the temperature generated by the heating of the separator, while increasing the freeze-drying speed.
★ sample pre-freezing system
The freeze-drying chamber has a refrigeration system that pre-freezing the sample prior to lyophilization. (Chinese Freezer Dryer can be set to pre-freeze temperature)
★ cold well defrost system
After the freeze-drying, rapid defrosting is performed on the cold so as to shorten the next freeze-drying time.
★ pure nitrogen reverse filling system (used for biological products)
To permanently store the sample, the counter-fill system can be used to fill the vacuum chamber with sterile air or nitrogen to protect the sample from contamination.
★ safety gland system
In order to permanently store the sample after lyophilization, in a vacuum state, a gland system is used to achieve a safe and precise sealing effect.
★ anti-vacuum pump oil reverse spray system
Anti-back spray device, protect the sample, to prevent the vacuum pump oil counter current to the system, pollution samples.
★ compressor secondary delay start system: to protect the compressor, to extend the service life of the compressor.
★ 1.5 km remote control.